Alterations in biochemical parameters of hyperlipidemia in coronary artery disease patients

An interaction between modified lipoproteins, monocytes derived macrophages, T-cells and normal cellular elements of the arterial wall results in the formation of atherosclerotic plaque. High levels of serum lipids and lipoproteins are a major risk factor for atherosclerosis. In this study, lipid profiles of hyperlipidemic patients with coronary artery disease were determined. The mean values of plasma total lipids (861.18±126.29 mg/dL), triglyceride (221.26±110.05 mg/dL), total cholesterol (219.68±51.64 mg/dL) and LDLcholesterol (134.3±41.70 mg/dL) were found to be significantly higher in hyperlipidemic patients as compared to normal individuals. In contrast, the plasma HDL-cholesterol was observed to be significantly reduced in the hyperlipidemic patients (37.5±9.37 mg/dL) as compared to normal individuals (51.3±7.9 mg/dL). Individuals with hyperlipidemia with increased LDL-cholesterol and reduced HDLcholesterol are highly susceptible to atherosclerosis.